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Article

Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein.

MicrobiologyOpen - 1 Oct 2015

Lannergård Jonas, Kristensen Bodil M, Gustafsson Mattias C U, Persson Jenny J, Norrby-Teglund Anna, Stålhammar-Carlemalm Margaretha, Lindahl Gunnar

Abstract excerpt

The M protein of Streptococcus pyogenes, a major bacterial virulence factor, has an amino-terminal hypervariable region (HVR) that is a target for type-specific protective antibodies. Intriguingly, the HVR elicits a weak antibody response, indicating that it escapes host immunity by two mechanisms, sequence variability and weak immunogenicity. However, the properties influencing the immunogenicity of regions in...

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Identifiers

PMID: 26175306
DOI: 10.1002/mbo3.278
PMCID: PMC4618610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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