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Article

Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jul 1993

Sussel L, Vannier D, Shore D

Abstract excerpt

In this study, we used the ADE2 gene in a colony color assay to monitor transcription from the normally silent HMR mating-type locus in Saccharomyces cerevisiae. This sensitive assay reveals that some previously identified cis- and trans-acting mutations destabilize silencing, causing genetically identical cells to switch between repressed and derepressed transcriptional states. Deletion of the autonomously...

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Identifiers

PMID: 8321199
DOI: 10.1128/mcb.13.7.3919-3928.1993
PMCID: PMC359929

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Source receipt: pubmed, retrieved 7 Sept 2026.

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