Article
Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jul 1993
Sussel L, Vannier D, Shore D
Abstract excerpt
In this study, we used the ADE2 gene in a colony color assay to monitor transcription from the normally silent HMR mating-type locus in Saccharomyces cerevisiae. This sensitive assay reveals that some previously identified cis- and trans-acting mutations destabilize silencing, causing genetically...
Topics
- Cloning, Molecular
- Diploidy
- Fungal Proteins
- GTP-Binding Proteins
- Genes, Fungal
- Genes, Mating Type, Fungal
- Genes, Switch
- Genes, Tumor Suppressor
- Mutation
- Phenotype
- Saccharomyces cerevisiae
- Transcription Factors
- Transcription, Genetic
- rap GTP-Binding Proteins