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Article

A cell cycle and mutational analysis of anchorage-independent growth: cell adhesion and TGF-beta 1 control G1/S transit specifically.

The Journal of cell biology - 1 Jul 1993

Han E K, Guadagno T M, Dalton S L, Assoian R K

Abstract excerpt

We have examined cell cycle control of anchorage-independent growth in nontransformed fibroblasts. In previous studies using G0-synchronized NRK and NIH-3T3 cells, we showed that anchorage-independent growth is regulated by an attachment-dependent transition at G1/S that resembles the START contr...

Topics

3T3 Cells
Animals
Cell Adhesion
Cell Count
Clone Cells
Contact Inhibition
Epidermal Growth Factor
G1 Phase
Hydroxyurea
Mice
Mitogens
Mitosis
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

S Phase

Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 8320267
DOI: 10.1083/jcb.122.2.461
PMCID: PMC2119643

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8320267-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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