Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

doi:10.1002/j.1460-2075.1992.tb05488.x

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Article

Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

The EMBO journal - 1 Nov 1992

Renshaw M W, Kipreos E T, Albrecht M R, Wang J Y

Abstract excerpt

The v-abl oncogene of Abelson murine leukemia virus (A-MuLV) induces two opposite phenotypes in NIH3T3 cells. In the majority of cells, v-abl causes a growth arrest at the G1 phase of the cell cycle; while in a minority of cells, v-abl abrogates the requirement for growth factors. Using temperatu...

Topics

3T3 Cells
Abelson murine leukemia virus
Animals
Cell Cycle
Cell Division
Cell Fusion
Cell Transformation, Neoplastic
Clone Cells
Genes, abl
Genetic Variation
Kinetics
Mice
Oncogene Proteins v-abl
Phenotype
Protein-Tyrosine Kinases
Transfection

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