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Article

High prevalence of mutations in the p53 gene in poorly differentiated squamous cell carcinomas in xeroderma pigmentosum patients.

The Journal of investigative dermatology - 1 Sept 1995

Matsumura Y, Sato M, Nishigori C, Zghal M, Yagi T, Imamura S, Takebe H

Abstract excerpt

Mutations in the p53 gene were analyzed in 23 squamous cell carcinomas (SCCs) and five basal cell carcinomas from 10 xeroderma pigmentosum patients in Tunisia. Fourteen mutations were detected. Most occurred at the dipyrimidine sequences of DNA, suggesting that they were caused by ultraviolet light. A strong correlation was noted between the presence of the p53 mutations and clinical characteristics such as...

Topics

Adolescent
Adult
Base Sequence
Carcinoma, Squamous Cell
Child
Genes, p53
Humans
Molecular Probes
Molecular Sequence Data
Mutation
Skin Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Xeroderma Pigmentosum

Source

Identifiers

PMID: 7665920
DOI: 10.1111/1523-1747.ep12321051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7665920-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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High prevalence of mutations in the p53 gene in poorly differentiated squamous cell carcinomas in xeroderma pigmentosum patients.PMID 7665920Read ↗

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