Article
Molecular genetics of Alzheimer's disease in Italian families.
Neurochemistry international - 1 Jul 1994
Sorbi S, Nacmias B, Mortilla M, Forleo P, Piacentini S, Amaducci L
Abstract excerpt
We screened 11 families from different regions of Italy by direct sequencing of exon 17 of the APP gene. Two unrelated families carried the APP717 mutation segregating with the disease. These two families originate from two Italian regions which are considered genetically separate. Published studies have demonstrated the presence of the APP717 Val-->Ile mutation in kindreds of British or Japanese origin with...
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