Article
Expression of mutant p53 protein in hepatocellular carcinoma.
Gut - 1 Jan 1994
Collier J D, Carpenter M, Burt A D, Bassendine M F
Abstract excerpt
p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected immunohistochemically because of its longer half life in comparison with native protein. This study...
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