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Article

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities.

Science (New York, N.Y.) - 4 Feb 1994

Rebar E J, Pabo C O

Abstract excerpt

A phage display system was developed and used to select zinc finger proteins with altered DNA-binding specificities. The three zinc fingers of the Zif268 protein were expressed on the surface of filamentous phage, and a library of variants was prepared by randomizing critical amino acids in the first zinc finger. Affinity selections, using DNA sites with base changes in the region recognized by the first finger,...

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Source

Identifiers

PMID: 8303274
DOI: 10.1126/science.8303274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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