Article
Specific RNA binding by a single C2H2 zinc finger.
The Journal of biological chemistry - 19 Jan 2001
Friesen W J, Darby M K
Abstract excerpt
Zinc finger proteins with high affinity for human immunodeficiency virus Rev responsive element stem loop IIB (RRE-IIB) were previously isolated from a phage display zinc finger library. Zinc fingers from one of these proteins, RR1, were expressed individually and assayed for RRE-IIB affinity. The C-terminal zinc finger retained much of the binding affinity of the two-finger parent and was disrupted by mutations...
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