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Article

Surface plasmon resonance based kinetic studies of zinc finger-DNA interactions.

Journal of immunological methods - 14 Jun 1995

Yang W P, Wu H, Barbas C F

Abstract excerpt

Libraries of the zinc finger DNA binding protein, Zif268, have been constructed and selected for affinity and specificity toward DNA targets using the phage display technique (Wu et al., 1995). Mutant proteins were purified to homogeneity and were characterized for their ability to interact with their DNA targets using a real-time biomolecular interaction assay (BIA). One mutant protein, C7, bound the Zif268...

Topics

Base Sequence
Biosensing Techniques
DNA
DNA-Binding Proteins
Enzyme-Linked Immunosorbent Assay
Gene Library
Kinetics
Membrane Proteins
Molecular Sequence Data
Mutation
Spectrum Analysis

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Zinc Fingers

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Identifiers

PMID: 7602135
DOI: 10.1016/0022-1759(95)00048-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7602135-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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