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Article

Gli3 expression is affected in the morphogenetic mouse mutants add and Xt.

Progress in clinical and biological research - 1 Jan 1993

Schimmang T, van der Hoeven F, Rüther U

Abstract excerpt

We investigated the relation between the recessive mutation add caused by insertional mutagenesis of a transgene and the dominant mutation extra-toes (Xt) which display similar effects on limb morphogenesis. The transgene insertion in add mapped close to the 5' end of the zinc finger gene Gli3 and 5'sequences of Gli3 were deleted in Xt. Expression analysis revealed a reduction of the Gli3 RNA level in both add...

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PMID: 8302891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Gli3 expression is affected in the morphogenetic mouse mutants add and Xt.PMID 8302891Read ↗

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).Semantic proximity Read ↗

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.Semantic proximity Read ↗

Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt).Semantic proximity Read ↗

Molecular linkage of the morphogenetic mutation add and the zinc finger gene Gli3.Semantic proximity Read ↗

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt).Semantic proximity Read ↗

Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects.Semantic proximity Read ↗

Involvement of the Gli3 (extra-toes) gene region in body weight in mice.Semantic proximity Read ↗

A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.Semantic proximity Read ↗

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.Semantic proximity Read ↗

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The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene.Semantic proximity Read ↗

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