A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.

doi:10.1038/ng0393-241

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Article

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.

Nature genetics - 1 Mar 1993

Hui C C, Joyner A L

Abstract excerpt

Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder affecting limb and craniofacial development. Recently, the human GLI3 gene has been proposed to be a candidate gene for GCPS. Here we describe the molecular characterization of extra-toes (Xt), which is a mouse model of...

Topics

Alleles
Animals
Blotting, Southern
DNA
Disease Models, Animal
Embryo, Mammalian
Facial Bones
Gene Deletion
Homozygote
Humans
Introns
Mice
Mice, Inbred C3H
Mice, Mutant Strains
Phenotype
Skull
Syndactyly
Syndrome

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