Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt).

Abstract excerpt

A recessive mutant caused by insertional mutagenesis in transgenic mice has been detected in which the anterior part of the forelimb is disorganized. The morphology of the thumb is always altered and sometimes the adjacent finger has an extra phalanx. This phenotype suggests that a body plan gene is affected. We have named the mutation add (anterior digit-pattern deformity). Using the cloned DNA from the flanking...

Topics

• Alleles
• Animals
• Bone and Bones
• Genes, Recessive
• Hindlimb
• Mice
• Mice, Transgenic
• Molecular Probe Techniques
• Mutagenesis, Insertional
• Phenotype
• Polymorphism, Restriction Fragment Length