Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).

doi:10.1242/dev.116.3.799

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Article

Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).

Development (Cambridge, England) - 1 Nov 1992

Schimmang T, Lemaistre M, Vortkamp A, Rüther U

Abstract excerpt

Genetic analysis and homology between the phenotypic alterations of the human Greig Cephalopolysyndactyly Syndrome (GCPS) and the mouse mutant extra-toes (Xt) have suggested a dominant mutation in the same gene of both species. Recently, the GLI3 gene, a member of the Krüppel-related zinc finger...

Topics

Abnormalities, Multiple
Animals
Brain
Extremities
Gene Expression
Genes
Mice
Mice, Mutant Strains
Morphogenesis
Mutation
Phenotype
Zinc Fingers

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