The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene.

doi:10.1007/s003359900973

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Article

The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1999

Thien H, Rüther U

Abstract excerpt

Mutations in the Gli3 gene are associated with a preaxial polydactyly in several mouse mutants such as extra-toes (Xt). The semidominant mouse mutant Pdn (Polydactyly Nagoya) is characterized by a mild polydactyly on the anterior side of the hind limbs. Homozygous Pdn mice show a more severe polydactyly, additional skeletal malformations, and abnormal brain development. Herein, we report the molecular basis of...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
DNA-Binding Proteins
Kruppel-Like Transcription Factors
Mice
Mice, Inbred C3H
Mice, Mutant Strains
Mutation
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polydactyly

RNA, Messenger

Repressor Proteins

Retroelements

Transcription Factors

Xenopus Proteins

Zinc Finger Protein Gli3

Source

Open in PubMed

Identifiers

PMID: 10051311
DOI: 10.1007/s003359900973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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