Article
Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1994
Nakai J, Adams B A, Imoto K, Beam K G
Abstract excerpt
Each of the four repeats (or motifs) of voltage-gated ion channels is thought to contain six transmembrane segments (S1-S6). Mutational analyses indicate that S4 functions as a voltage sensor and that the S5, S6, and S5-S6 linker contribute to formation of the ion pore. However, little informatio...
Topics
- Amino Acid Sequence
- Animals
- Calcium Channels
- Calcium Channels, L-Type
- Cells, Cultured
- DNA, Complementary
- Kinetics
- Mice
- Molecular Sequence Data
- Muscle Proteins
- Muscles
- Mutation