Article
Expression and functional characterization of the cardiac L-type calcium channel carrying a skeletal muscle DHP-receptor mutation causing hypokalaemic periodic paralysis.
Pflugers Archiv : European journal of physiology - 1 Jan 1996
Lerche H, Klugbauer N, Lehmann-Horn F, Hofmann F, Melzer W
Abstract excerpt
A histidine substitution for the outermost arginine in II/S4 of the alpha1 subunit of the human skeletal muscle dihydropyridine (DHP) receptor has been reported to cause hypokalaemic periodic paralysis (HypoPP). This mutation shifts the voltage dependence of L-type Ca curent inactivation in myotu...
Topics
- Animals
- Arginine
- Barium
- Base Sequence
- Calcium Channels
- Calcium Channels, L-Type
- Histidine
- Humans
- Hydrogen-Ion Concentration
- Hypokalemia
- Ion Channels
- Molecular Sequence Data