Article
Polymorphism at codon 36 of the p53 gene.
Oncogene - 1 Jan 1994
Felix C A, Brown D L, Mitsudomi T, Ikagaki N, Wong A, Wasserman R, Womer R B, Biegel J A
Abstract excerpt
A polymorphism at codon 36 in exon 4 of the p53 gene was identified by single strand conformation polymorphism (SSCP) analysis and direct sequencing of genomic DNA PCR products. The polymorphic allele, present in the heterozygous state in genomic DNAs of four of 100 individuals (4%), changes the codon 36 CCG to CCA, eliminates a FinI restriction site and creates a BccI site. Including this polymorphism there are...
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