Article
Polymorphism in exon 4 of TP53 gene associated to HPV 16 and 18 in Mexican women with cervical cancer.
Medical oncology (Northwood, London, England) - 1 Dec 2011
Piña-Sánchez Patricia, Hernández-Hernández Dulce María, Taja-Chayeb Lucia, Cerda-Flores Ricardo M, González-Herrera Ana Lilia, Rodea-Avila Carlos, Apresa-García Teresa, Ostrosky-Wegman Patricia, Vázquez-Ortíz Guelaguetza, Mendoza-Lorenzo Patricia, Dueñas-González Alfonso, Salcedo Mauricio
Abstract excerpt
Cervical cancer (CC) is the second most common cancer in Mexican women. Human papillomavirus (HPV) infection is necessary but not sufficient for CC development. Furthermore, genetic factors as polymorphisms could be important susceptibility factors. Controversial results regarding TP53 polymorphisms specifically in codon 72 of CC have been reported. In the present work, the exon 4 sequence of TP53 gene in CC and...
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