Article
Alterations in exon 4 of the p53 gene in gastric carcinoma.
Gastroenterology - 1 Jun 2000
Shepherd T, Tolbert D, Benedetti J, Macdonald J, Stemmermann G, Wiest J, DeVoe G, Miller M A, Wang J, Noffsinger A, Fenoglio-Preiser C
Abstract excerpt
BACKGROUND & AIMS: Our long-term goal was to evaluate the role of p53 in the prognosis of gastric cancer. We previously showed a discrepancy between p53 expression and the presence of mutations when only exons 5-9 were examined. We then evaluated exon 4. METHODS: DNA was sequenced from 217 gastri...
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