Article
Effects on virulence of mutations in a locus essential for hyaluronic acid capsule expression in group A streptococci.
Infection and immunity - 1 Feb 1994
Wessels M R, Goldberg J B, Moses A E, DiCesare T J
Abstract excerpt
Mucoid or highly encapsulated strains of group A streptococci have been associated both with unusually severe infections and with acute rheumatic fever. Previously, we described an acapsular mutant, TX4, derived from a mucoid M-type 18 strain of a group A streptococcus by transposon mutagenesis (...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA Transposable Elements
- DNA, Bacterial
- Female
- Genes, Bacterial
- Glucuronosyltransferase
- Glycosyltransferases
- Humans
- Hyaluronan Synthases
- Hyaluronic Acid
- In Vitro Techniques
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Mutation