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Article

Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1991

Wessels M R, Moses A E, Goldberg J B, DiCesare T J

Abstract excerpt

Mucoid strains of group A Streptococcus have been associated with recent outbreaks of acute rheumatic fever. The mucoid colony morphology of these strains is a result of abundant production of capsular polysaccharide, which is composed of hyaluronic acid. To study the role of the hyaluronic acid capsule in virulence, we derived an acapsular mutant from a mucoid strain of group A Streptococcus by transposon...

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Identifiers

PMID: 1656437
DOI: 10.1073/pnas.88.19.8317
PMCID: PMC52499

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