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Article

Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1991

Wessels M R, Moses A E, Goldberg J B, DiCesare T J

Abstract excerpt

Mucoid strains of group A Streptococcus have been associated with recent outbreaks of acute rheumatic fever. The mucoid colony morphology of these strains is a result of abundant production of capsular polysaccharide, which is composed of hyaluronic acid. To study the role of the hyaluronic acid capsule in virulence, we derived an acapsular mutant from a mucoid strain of group A Streptococcus by transposon...

Topics

Animals
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
Blood Bactericidal Activity
Blotting, Southern
Carrier Proteins
DNA Mutational Analysis
DNA Transposable Elements
DNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hyaluronic Acid

Immunodiffusion

In Vitro Techniques

Mice

Phagocytosis

Phenotype

Polysaccharides, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 1656437
DOI: 10.1073/pnas.88.19.8317
PMCID: PMC52499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656437-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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