Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.

doi:10.1242/dev.121.8.2525

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Aug 1995

Church D L, Guan K L, Lambie E J

Abstract excerpt

In the germline of Caenorhabditis elegans hermaphrodites, meiotic cell cycle progression occurs in spatially restricted regions. Immediately after leaving the distal mitotic region, germ cells enter meiosis and thereafter remain in the pachytene stage of first meiotic prophase for an extended period. At the dorsoventral gonadal flexure, germ cells exit pachytene and subsequently become arrested in diakinesis. We...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Female
Genes, Helminth
Helminth Proteins
MAP Kinase Kinase 2
Male
Meiosis
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mosaicism

Mutation

Oogenesis

Prophase

Protein Serine-Threonine Kinases

Protein-Tyrosine Kinases

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7671816
DOI: 10.1242/dev.121.8.2525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7671816-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.PMID 7671816Read ↗

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.Semantic proximity Read ↗

Multiple Functions and Dynamic Activation of MPK-1 Extracellular Signal-Regulated Kinase Signaling in<i>Caenorhabditis elegans</i>Germline DevelopmentSemantic proximity Read ↗

Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans.Semantic proximity Read ↗

Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.Semantic proximity Read ↗

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.Semantic proximity Read ↗

Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germlineSemantic proximity Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.