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Article

Isolation of a mutant allele that deregulates the threonine biosynthesis in Saccharomyces cerevisiae.

Current genetics - 1 Dec 1993

Martin-Rendon E, Farfán M J, Ramos C, Calderon I L

Abstract excerpt

We have cloned the yeast allele HOM3-R2, that codes for a mutant aspartate kinase which is insensitive to feedback inhibition by threonine, by gap-repair. A strain carrying this allele in a multicopy plasmid, or integrated into the genome, accumulates 14-times and 8-times more threonine than the wild-type, respectively. The sequence of the mutant allele differs from that of the wild-type in a single base pair...

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PMID: 8299165
DOI: 10.1007/BF00351707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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