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Article

Threonine biosynthetic genes are essential in Cryptococcus neoformans.

Microbiology (Reading, England) - 1 Sept 2008

Kingsbury Joanne M, McCusker John H

Abstract excerpt

We identified and attempted to disrupt the Cryptococcus neoformans homoserine and/or threonine biosynthetic genes encoding aspartate kinase (HOM3), homoserine kinase (THR1) and threonine synthase (THR4); however, each gene proved recalcitrant to disruption. By replacing the endogenous promoters of HOM3 and THR1 with the copper-repressible CTR4-1 promoter, we showed that HOM3 and THR1 were essential for the growth...

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Identifiers

PMID: 18757810
DOI: 10.1099/mic.0.2008/019729-0
PMCID: PMC2674386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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