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Article

Threonine overproduction in yeast strains carrying the HOM3-R2 mutant allele under the control of different inducible promoters.

Applied and environmental microbiology - 1 Jan 1999

Farfán M J, Aparicio L, Calderón I L

Abstract excerpt

The HOM3 gene of Saccharomyces cerevisiae codes for aspartate kinase, which plays a crucial role in the regulation of the metabolic flux that leads to threonine biosynthesis. With the aim of obtaining yeast strains able to overproduce threonine in a controlled way, we have placed the HOM3-R2 mutant allele, which causes expression of a feedback-insensitive enzyme, under the control of four distinctive regulatable...

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Identifiers

PMID: 9872767
DOI: 10.1128/AEM.65.1.110-116.1999
PMCID: PMC90990

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