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Article

Mutations that cause threonine sensitivity identify catalytic and regulatory regions of the aspartate kinase of Saccharomyces cerevisiae.

Yeast (Chichester, England) - 30 Sept 1999

Arévalo-Rodríguez M, Calderón I L, Holmberg S

Abstract excerpt

The HOM3 gene of Saccharomyces cerevisiae encodes aspartate kinase, which catalyses the first step in the branched pathway leading to the synthesis of threonine and methionine from aspartate. Regulation of the carbon flow into this pathway takes place mainly by feedback inhibition of this enzyme by threonine. We have isolated and characterized three HOM3 mutants that show growth inhibition by threonine due to a...

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PMID: 10509015
DOI: 10.1002/(SICI)1097-0061(19990930)15:13<1331::AID-YEA460>3.0.CO;2-W

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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