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Article

Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization.

Journal of molecular biology - 19 May 2000

Pierce M M, Nall B T

Abstract excerpt

The effect of His-heme misligation on folding has been investigated for a triple mutant of yeast iso-2 cytochrome c (N26H,H33N,H39K iso-2). The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1. The amplitude for fast phase folding exhibits a strong initial pH dependence. For...

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Identifiers

PMID: 10801361
DOI: 10.1006/jmbi.2000.3700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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