Article
Failure to find linkage between schizophrenia and genetic markers on chromosome 21.
American journal of medical genetics - 15 Oct 1993
Asherson P, Mant R, Taylor C, Sargeant M, Collier D, Clements A, Nanko S, Whatley S, Gill M, McGuffin P
Abstract excerpt
We sought evidence for the involvement of mutations in the amyloid precursor protein gene (APP) in the pathogenesis of schizophrenia in two ways. First, linkage analysis was performed in a sample of 24 families multiply affected with schizophrenia. The genotypes were studied for GT12 (D21S210), a highly polymorphic microsatellite marker at the APP locus. Second, we used single strand conformation analysis (SSCA)...
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