Article
Linkage study of chromosome 6p in sib-pairs with schizophrenia.
American journal of medical genetics - 31 May 1997
Daniels J K, Spurlock G, Williams N M, Cardno A G, Jones L A, Murphy K C, Asherson P, Holmans P, Fenton I, McGuffin P, Owen M J
Abstract excerpt
Following reports of linkage between schizophrenia and markers in the chromosomal region 6p24-22 we have studied nine microsatellite markers spanning 40 cM of this region in our sample of 102 affected sibling pairs from 86 families. Allele sharing identity by descent was examined using likelihood based sib-pair analysis as implemented by the program SPLINK. No evidence for linkage was obtained and the highest lod...
Topics
- Adult
- Alleles
- Chromosomes, Human, Pair 6
- Disease Susceptibility
- Female
- Genetic Linkage
- Genotype
- Humans
- Lod Score
- Male
- Microsatellite Repeats
- Nuclear Family
- Schizophrenia
- Software