A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila.

doi:10.1101/gad.8.1.84

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Article

A weak germ-line excision mutation blocks developmentally controlled amplification of the rDNA minichromosome of Tetrahymena thermophila.

Genes & development - 1 Jan 1994

Kapler G M, Blackburn E H

Abstract excerpt

During development of the somatic macronucleus of Tetrahymena thermophila, the rDNA is excised from its germ-line chromosome, rearranged into a palindrome, and amplified to 10(4) copies. We have identified a cis-acting germ-line mutation, rmm11/6, that prevents amplification of the rDNA in all bu...

Topics

Animals
Blotting, Southern
Chromosomes
DNA Replication
DNA, Ribosomal
Gene Amplification
Germ Cells
Mutation
Phenotype
RNA, Protozoan
Tetrahymena thermophila

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