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Article

Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement.

Molecular and cellular biology - 1 Sept 2009

Bednenko Janna, Noto Tomoko, DeSouza Leroi V, Siu K W Michael, Pearlman Ronald E, Mochizuki Kazufumi, Gorovsky Martin A

Abstract excerpt

In conjugating Tetrahymena thermophila, massive DNA elimination occurs upon the development of the new somatic genome from the germ line genome. Small, approximately 28-nucleotide scan RNAs (scnRNAs) and Twi1p, an Argonaute family member, mediate H3K27me3 and H3K9me3 histone H3 modifications, which lead to heterochromatin formation and the excision of the heterochromatinized germ line-limited sequences. In our...

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Identifiers

PMID: 19596782
DOI: 10.1128/MCB.00076-09
PMCID: PMC2738283

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