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Article

Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.

Genetics - 1 Jun 1994

Kapler G M, Orias E, Blackburn E H

Abstract excerpt

The abundant rDNA minichromosome of Tetrahymena thermophila is generated by a series of developmentally controlled processing steps, termed rDNA maturation, during the formation of the new macronucleus in conjugating cells. rDNA maturation involves excision of a region encoding the single copy rRNA gene (rDNA) from its germline location, rearrangement of the rDNA into a palindromic minichromosome, de novo...

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Identifiers

PMID: 8070657
DOI: 10.1093/genetics/137.2.455
PMCID: PMC1205969

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Tetrahymena thermophila mutants defective in the developmentally programmed maturation and maintenance of the rDNA minichromosome.PMID 8070657Read ↗

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The intranuclear organization of normal, hemizygous and excision-deficient rRNA genes during developmental amplification in Tetrahymena thermophila.Semantic proximity Read ↗

Deletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genome.Semantic proximity Read ↗

TIF1 Represses rDNA replication initiation, but promotes normal S phase progression and chromosome transmission in Tetrahymena.Semantic proximity Read ↗

A promoter region mutation affecting replication of the Tetrahymena ribosomal DNA minichromosome.Semantic proximity Read ↗

The transition from conjugal development to the first vegetative cell division is dependent on RAD51 expression in the ciliate Tetrahymena thermophila.Semantic proximity Read ↗

Germ line transcripts are processed by a Dicer-like protein that is essential for developmentally programmed genome rearrangements of Tetrahymena thermophila.Semantic proximity Read ↗

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