Article
Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males.
Pharmacogenetics - 1 Oct 1993
Rothman N, Hayes R B, Bi W, Caporaso N, Broly F, Woosley R L, Yin S, Feng P, You X, Meyer U A
Abstract excerpt
Eighty-four healthy Chinese male control subjects derived from an occupation-based case-control study of bladder cancer were evaluated for hepatic N-acetyltransferase activity by dapsone and for NAT2 genotype using allele-specific amplification of peripheral leukocyte DNA by the polymerase chain reaction. Fifty-nine percent of the overall variation in acetylation activity was explained by genotype (p < 0.0001)....
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