Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction.

Cancer research - 15 Aug 1998

Taylor J A, Umbach D M, Stephens E, Castranio T, Paulson D, Robertson C, Mohler J L, Bell D A

Abstract excerpt

Arylamines are known bladder carcinogens and are an important constituent of tobacco smoke. The handling of arylamines in the body is complex and includes metabolism by NAT1 and NAT2, enzymes that play a role in both activation and detoxification of arylamines and their congeners. Both NAT1 and NAT2 are polymorphic, with alleles that have been shown to correlate with higher or lower enzyme activity. To explore...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Black People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Isoenzymes

Share to Neoplasm Proteins

Share to Polymorphism, Genetic

Share to Smoking

Source

Identifiers

PMID: 9721868

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction.PMID 9721868Read ↗

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.Semantic proximity Read ↗

N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.Semantic proximity Read ↗

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.Semantic proximity Read ↗

Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer.Semantic proximity Read ↗

Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10.Semantic proximity Read ↗

N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort.Semantic proximity Read ↗

Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction.Semantic proximity Read ↗

Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.Semantic proximity Read ↗

Evaluating interactions of polygenic risk scores and NAT2 genotypes with tobacco smoking in bladder cancer risk.Semantic proximity Read ↗

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.Semantic proximity Read ↗

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.Semantic proximity Read ↗

Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.