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<i>ethA</i> , <i>inhA</i> , and <i>katG</i> Loci of Ethionamide-Resistant Clinical <i>Mycobacterium tuberculosis</i> Isolates

24 Nov 2003

Abstract excerpt

Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA, an enzyme involved in mycolic acid biosynthesis. INH requires catalase-peroxidase (KatG) activation, and mutations in katG are a major INH resistance mechanism. Recently an enzyme (EthA) capable of activating ETH has been identified. We sequenced the entire ethA structural gene of 41...

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PMID: 14638486
DOI: 10.1128/aac.47.12.3799-3805.2003

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