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Replication of Coxsackievirus B3 in Primary Cell Cultures Generates Novel Viral Genome Deletions

6 Dec 2007

Abstract excerpt

Coxsackievirus B3 (CVB3) generates 5'-terminally deleted genomes (TDs) during replication in murine hearts. We show here that CVB3 populations with TDs can also be generated within two to three passages of CVB3 in primary, but not immortalized, cell cultures. Deletions of less than 49 nucleotides increase in size during passage, while 5' TDs of 49 nucleotides appear to be the maximum deletion size. The cellular...

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PMID: 18057248
DOI: 10.1128/jvi.01774-07

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Replication of Coxsackievirus B3 in Primary Cell Cultures Generates Novel Viral Genome DeletionsPMID 18057248Read ↗

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