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A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes

10 Feb 2023

Abstract excerpt

We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat model from commercially available inbred rats. We made reciprocal crosses between males and females from the 2 F1 hybrids to generate genetically heterogeneous rats with...

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PMID: 36762848
DOI: 10.1093/gerona/glad056

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