Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies.

doi:10.1534/g3.117.300495

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Article

Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies.

G3 (Bethesda, Md.) - 2 Feb 2018

Brekke Thomas D, Steele Katherine A, Mulley John F

Abstract excerpt

Nonmodel rodents are widely used as subjects for both basic and applied biological research, but the genetic diversity of the study individuals is rarely quantified. University-housed colonies tend to be small and subject to founder effects and genetic drift; so they may be highly inbred or show substantial genetic divergence from other colonies, even those derived from the same source. Disregard for the levels...

Topics

Animals
Animals, Inbred Strains
Animals, Outbred Strains
Cricetinae
Female
Founder Effect
Genetic Drift
Genetic Variation
Genetics, Population
Gerbillinae
High-Throughput Nucleotide Sequencing
Male
Mice
Polymorphism, Genetic
Rats

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Identifiers

PMID: 29242387
DOI: 10.1534/g3.117.300495
PMCID: PMC5919727

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