Article
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995
Santra M, Skorski T, Calabretta B, Lattime E C, Iozzo R V
Abstract excerpt
The rapid progress in the cloning of proteoglycan genes has enabled investigators to examine in depth the functional roles these polyhedric molecules play in the control of cell proliferation. Decorin, a leucine-rich proteoglycan expressed by most connective tissues, is a prototype molecule that...
Topics
- Antisense Elements (Genetics)
- Carcinoma
- Cell Cycle
- Colonic Neoplasms
- Decorin
- Extracellular Matrix Proteins
- Gene Expression
- Genes, Tumor Suppressor
- Humans
- Neoplasms, Experimental
- Phenotype
- Proteoglycans
- Transfection