Article
UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 1994
Nakazawa H, English D, Randell P L, Nakazawa K, Martel N, Armstrong B K, Yamasaki H
Abstract excerpt
Many human skin tumors contain mutated p53 genes that probably result from UV exposure. To investigate the link between UV exposure and p53 gene mutation, we developed two methods to detect presumptive UV-specific p53 gene mutations in UV-exposed normal skin. The methods are based on mutant allele-specific PCRs and ligase chain reactions and designed to detect CC to TT mutations at codons 245 and 247/248, using...
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