Article
An approximate maximum likelihood approach, applied to phylogenetic trees.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2003
Jönsson Henrik, Söderberg Bo
Abstract excerpt
A novel type of approximation scheme to the maximum likelihood (ML) approach is presented and discussed in the context of phylogenetic tree reconstruction from aligned DNA sequences. It is based on a parameterized approximation to the conditional distribution of hidden variables (related, e.g., to the sequences of unobserved branch point ancestors) given the observed data. A modified likelihood, based on the...
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