Article
Molecular and clinical study of familial adenomatous polyposis for genetic testing and management.
Journal of experimental & clinical cancer research : CR - 1 Dec 1999
Li G, Tamura K, Yamamoto Y, Sashio H, Utsunomiya J, Yamamura T, Shimoyama T, Furuyama J
Abstract excerpt
Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer characterized by the development of numerous adenomatous polyps, predominantly in the colorectal region. Germline mutations of the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis. We examined germline mutations of the APC gene and clinical features among eighty-seven individuals who...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Child
- Child, Preschool
- Codon
- DNA Primers
- Family
- Female
- Genes, APC
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Male