Article
Molecular genetic evidence for the delineation of a more severe form of familial adenomatous polyposis which results from fresh mutation.
Annals of human genetics - 1 May 1993
Rees M, Leigh S E, Delhanty J D, Bowles L, Talbot I C
Abstract excerpt
Familial adenomatous polyposis, an inherited pre-malignant condition, is caused by mutation in the adenomatous polyposis coli (APC) gene at chromosome 5q22. The lifetime risk of carcinoma approaches 100%, with an average age at death from cancer of 40 years, allowing most patients to complete rep...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- DNA Mutational Analysis
- Female
- Genes, APC
- Genes, ras
- Heterozygote
- Humans
- Male
- Middle Aged
- Mutation