Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer

29 Apr 2015

Abstract excerpt

The current understanding of the molecular mechanisms that lead to cancer is not sufficient to explain the loss or gain of function in proteins related to tumorigenic processes. Among them, more than 100 oncogenes, 20-30 tumor-suppressor genes, and hundreds of genes participating in DNA repair and replication have been found to play a role in the origins of cancer over the last 25 years. The phosphorylation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Chronic Lymphocytic Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25973395
DOI: 10.3389/fonc.2015.00097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human CancerPMID 25973395Read ↗

Structural biology of the tumor suppressor p53 and cancer-associated mutants.Semantic proximity Read ↗

p53—A Natural Cancer Killer: Structural Insights and Therapeutic ConceptsSemantic proximity Read ↗

Prion-like p53 Amyloids in CancerSemantic proximity Read ↗

The Status of p53 Oligomeric and Aggregation States in CancerSemantic proximity Read ↗

Prion-like aggregation of mutant p53 in cancer.Semantic proximity Read ↗

Structural biology of the tumor suppressor p53.Semantic proximity Read ↗

Reactivation of mutant p53: molecular mechanisms and therapeutic potential.Semantic proximity Read ↗

[Advances on mutant p53 research].Semantic proximity Read ↗

Mutations, protein homeostasis, and epigenetic control of genome integrity.Semantic proximity Read ↗

p53: From Fundamental Biology to Clinical Applications in CancerSemantic proximity Read ↗

p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis.Semantic proximity Read ↗

p53: Multiple Facets of a Rubik's CubeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.