Article
Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers.
Therapeutic drug monitoring - 1 Jun 1992
Llerena A, Dahl M L, Ekqvist B, Bertilsson L
Abstract excerpt
We have previously shown that the disposition of haloperidol is decreased in poor (PM) compared to extensive (EM) metabolizers of debrisoquine. We now report that the plasma levels of the reduced metabolite of haloperidol, after a single 2- or 4-mg oral dose of the parent drug, are significantly...
Topics
- Chromatography, High Pressure Liquid
- Debrisoquin
- Haloperidol
- Humans
- Hydroxylation
- Oxidation-Reduction
- Phenotype