Article
Calcium-activated neutral protease (CANP) in normal and dysmyelinating mutant paralytic tremor rabbit myelin.
Molecular and chemical neuropathology - 1 Jun 1992
Domańska-Janik K, de Nechaud B, Inomata M, Kawashima S, Zalewska T
Abstract excerpt
Calcium-activated neutral protease (CANP) in normal and dysmyelinating mutant, paralytic tremor (PT) rabbit myelin and premyelin fractions was studied using immature (4-5 wk) or adult animals. The enzyme was estimated by determination of its catalytic activity as well as by using immunoblot analysis after SDS-PAGE separation. The presence of two forms of CANP--one activated by calcium in the micromolar...
Topics
- Animals
- Brain Chemistry
- Calpain
- Demyelinating Diseases
- Isoenzymes
- Muscle Proteins
- Mutation
- Myelin Proteins
- Myelin Sheath
- Paralysis
- Rabbits
- Tremor
