Article
Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1993
Onisto M, Garbisa S, Caenazzo C, Freda M P, Di Francesco C, Nitti D, Liotta L A, Stetler-Stevenson W G
Abstract excerpt
The matrix metalloproteinase enzymes have been implicated in tumor invasion and metastasis by a series of correlative immunohistochemical studies. In addition, direct evidence for the role of these enzymes in this pathologic process comes from studies using specific metalloproteinase inhibitors to block tumor invasion and metastasis formation, both in vitro and in vivo. Synthetic oligonucleotide primers for four...
Topics
- Base Sequence
- Colorectal Neoplasms
- DNA Primers
- Glycoproteins
- Humans
- Metalloendopeptidases
- Molecular Sequence Data
- Neoplasm Invasiveness
- Neoplasm Proteins
- Phenotype
- Polymerase Chain Reaction
- RNA, Messenger
- Tissue Inhibitor of Metalloproteinase-2