Article
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations.
Molecular and cellular biology - 1 Aug 1997
Pang Q, Prolla T A, Liskay R M
Abstract excerpt
The MutL protein is an essential component of the Escherichia coli methyl-directed mismatch repair system but has no known enzymatic function. In the yeast Saccharomyces cerevisiae, the MutL equivalent, an Mlh1p and Pms1p heterodimer, interacts with Msh2p bound to mismatch-containing DNA. Little...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA
- DNA Repair
- Dimerization
- Fungal Proteins
- Humans
- Molecular Sequence Data
- MutL Protein Homolog 1