Article
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.
Molecular biology of the cell - 1 Oct 2003
Murakami Yoshiko, Siripanyapinyo Uamporn, Hong Yeongjin, Kang Ji Young, Ishihara Sonoko, Nakakuma Hideki, Maeda Yusuke, Kinoshita Taroh
Abstract excerpt
Many cell surface proteins are anchored to a membrane via a glycosylphosphatidylinositol (GPI), which is attached to the C termini in the endoplasmic reticulum. The inositol ring of phosphatidylinositol is acylated during biosynthesis of GPI. In mammalian cells, the acyl chain is added to glucosaminyl phosphatidylinositol at the third step in the GPI biosynthetic pathway and then is usually removed soon after the...
Topics
- Acylation
- Acyltransferases
- Amino Acid Sequence
- Animals
- CHO Cells
- Cell Membrane
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- Cricetulus
- Endoplasmic Reticulum
- Glycosylphosphatidylinositols
- Humans